Описание
Ксалкори (Кризотиниб) — это противоопухолевый препарат, который содержит в качестве активного вещества кризотиниб. Препарат применяется для лечения взрослых пациентов с немелкоклеточным раком легкого, у которых присутствует определенная перестройка (дефект) в гене, называемом киназа анапластической лимфомы (АLК). Люди с таким геном расположены к развитию аденокарциномы легкого, даже если они не курят. Препарат Ксалкори может сдержать или полностью остановить прогрессирование немелкоклеточного рака легкого (НМРЛ), а также сократить размеры опухоли.
Действие препарата основано на том, что активное вещество кризотиниб ингибирует разрастание кровоснабжающих опухоль сосудов. В следствии этого опухоль становится менее опасной.
Как правило, НМРЛ обнаруживают на 2 или на 3 стадии. И даже в этих случаях Ксалкори является эффективным препаратом.
Состав
- Действующее вещество: 200 мг кризотиниба или 250 мг кризотиниба
- Компоненты капсулы: диоксид кремния коллоидный, целлюлоза микрокристаллическая, гидрофосфат кальция безводный, натрия крахмалгликолят, стеарат магния.
- Оболочка капсулы: желатин, диоксид титана, оксид железа красный.
- Чернила: шеллак, пропиленгликоль, раствор аммиака концентрированный, гидроксид калия, оксид железа черный.
Применение
- для первичной терапии распространенной немелкоклеточный рака легких (НМРЛ). Он назначается на поздней стадии заболевания и в случае неэффективности предшествующей терапии.
- экспрессирующий киназу анапластической лимфомы (ALK).
Фармакодинамика
Кризотиниб является низкомолекулярным селективным ингибитором рецепторов тирозинкиназы (RTK), в том числе киназы анапластической лимфомы (ALK) и его онкогенных разновидностей (т.е. продуктов слияния ALK и отдельных ее мутаций). Кризотиниб — это также и ингибитор рецепторов фактора роста гепатоцитов. В зависимой от степени концентрации кризотиниб подавляет активность ALK и c-Met в биохимических тестах, а также подавляет процесс фосфорилирования и модулирует киназозависимые фенотипы в рамках клеточных анализов. Кризотиниб характеризуется мощной и избирательной ингибиторной активностью и индуцирует апоптоз у опухолевых клеток, экспрессирующих вещества слияния ALK (в т. ч. EML4-ALK и NPM-ALK) либо демонстрирующих амплификацию MET или ALK. Противоопухолевое действие кризотиниба дозозависимо и взаимосвязано с проявлением фармакодинамического подавления фосфорилирования результатов слияния ALK (также EML4-ALK и NPM-ALK) в опухолях.
Фармакокинетика
Всасывание
Время достижения максимальной концентрации в плазме крови после однократного перорального приема препарата натощак составляет от 4 до 6 часов. При приеме кризотиниба в дозе 250 мг 2 раза/сутки равновесная концентрация вещества достигается в течение 2 недель (15 дней) и остается постоянной, при этом средний коэффициент накопления равен 4.8. В диапазоне доз 200 мг-300 мг 2 раза/сутки максимальная концентрация в плазме (Cmax) и площадь под кривой «концентрация-время» (AUC) возрастают в большей степени сравнительно принятой дозы.
При однократном пероральном приеме в дозе 250 мг абсолютная биодоступность кризотиниба составляет 43%.
При однократном приеме кризотиниба в дозе 250 мг прием пищи с высоким содержанием жиров у здоровых добровольцев снижает значения AUC и Cmax приблизительно на 14%. Следовательно, кризотиниб можно принимать вне зависимости от приема еды.
Связывание кризотиниба с белками плазмы крови in vitro составляет 91%, вне зависимости от концентрации. По данным исследований in vitro считается, что кризотиниб является основой для P-гликопротеина. Коэффициент соотношения концентрации в плазме или крови составляет приблизительно 1. Связывание кризотиниба с белками плазмы крови составляет 91% и не зависит от концентрации лекарственного препарата. Средний объем распределения (Vss) кризотиниба составляет 1 772 л после внутривенного введения в дозе 50 мг, что показывает о обширном распределении в ткани.
Выведение
In vitro было показано, что клиренс вещества преимущественно осуществляется изоферментами CYP3A4 и CYP3A5. Основными путями метаболизма у человека являются процесс окисления пиперидинового кольца с образованием лактама кризотиниба и реакция O-деалкилирования с дальнейшим конъюгированием O-деалкилированных метаболитов второй фазы. Терминальный период полувыведения из плазмы крови при однократном приеме кризотиниба составлял 42 часа.
При однократном приеме меченного радиоактивным изотопом 250 мг препарата здоровыми добровольцами 63% и 22% принятой дозы выводится через кишечник и почки, соответственно. При этом приблизительно 53% и 2.3% принятой дозы приходилось на долю непреобразованного кризотиниба при выведении через кишечник и почки. В равновесной концентрации средний кажущийся клиренс кризотиниба был ниже (60 л/ч) после применения кризотиниба в дозе 250 мг 2 раза/сутки, чем после применения в дозе 250 мг 1 раз/сутки (100 л/ч). Судя по всему, это связано с увеличенным ингибирование изофермента CYP3A после приема нескольких доз.
Фармакокинетика у особых групп пациентов
Пациенты с нарушением функции почек
У больных с нарушением функции почек легкой степени и средней степени тяжести коррекция дозы препарата не требуется, потому что равновесные концентрации кризотиниба в этих случаях практически не отличаются от таковой у больных с нормальной функцией почек. Также, было установлено, что это никак не влияет на фармакокинетику кризотиниба.
У больных с тяжелой почечной недостаточностью, состояние которых не нуждается в проведении перитонеального диализа или гемодиализа, после однократного приема кризотиниба в дозе 250 мг AUC и Cmax кризотиниба повышались на 79% и 34%, соответственно. У таких пациентов следует корректировать дозу кризотиниба.
Не исследовалось применение кризотиниба у пациентов с тяжелым нарушением функции почек или находящихся на гемодиализе.
Пациенты с нарушением функции печени
Не исследовалось применение кризотиниба у больных с нарушением функции печени. В клинических исследованиях не принимали участие пациенты, у которых отмечали увеличение активности АСТ или АЛТ более чем в 2.5 раза относительно ВГН (более чем в 5 раз относительно ВГН по причине злокачественного новообразования) или повышение концентрации общего билирубина более чем в 1.5 раза относительно ВГН. По данным фармакокинетического популяционного анализа было установлено, что базовая концентрация общего билирубина или активность АСТ не влияют на фармакокинетику вещества. Ввиду того, что кризотиниб в большей степени метаболизируется печенью, можно ожидать повышения концентрации кризотиниба в плазме крови при нарушениях функции печени.
Возраст
Фармакокинетика кризотиниба не меняется в зависимости от возраста.
Этническая принадлежность
Было установлено, что предполагаемая равновесная AUC у жителей Азии на 23-37% выше, чем у представителей других этнических групп.
Применение у детей
Безопасность и эффективность кризотиниба у детей не установлены.
Фармацевтические характеристики
Ксалкори 200 мг — твердые желатиновые капсулы размером №1 . Капсулы с бело-розовым корпусом, непрозрачные. Имеют маркировку, нанесенную черными чернилами: «Pfizer» на крышечке и «CRZ 200» на корпусе.
Ксалкори 250 мг — твердые желатиновые капсулы размером №0 . Капсулы с розово-розовым корпусом, непрозрачные. Имеют маркировку, нанесенную черными чернилами: «Pfizer» на крышечке и «CRZ 250» на корпусе.
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