Описание
Золадекс (Zoladex) — гормональное противоопухолевое средство, аналог гонадотропин-рилизинг гормона. Используется для лечения рака предстательной железы у мужчин, эндометриоза и доброкачественных новообразований матки у женщин. В составе имеет активное вещество — Гозерелин (Goserelin).
Препарат поставляется в виде шприца-апликатора с предварительно заполненной капсулой (10.8 мг) для подкожной инъекции. Вводят препарат — мужчинам один раз в 13 недель, женщинам один раз в 12 недель.
Состав
- Активное вещество: гозерелин (в форме ацетата) 10.8 мг
- Вспомогательные вещества: сополимер молочной и гликолевой кислот.
Показания к применению
Для препарата Золадекс 10,8 мг
- рак предстательной железы;
- эндометриоз;
- фибромы матки.
Фармакодинамика
Золадекс является синтетическим аналогом природного гонадотропин-рилизинг гормона (ГнРГ). При постоянном применении гозерелин подавляет секрецию гипофизом лютеинизирующего гормона (ЛГ), что приводит к уменьшению концентрации тестостерона у мужчин в сыворотке крови и концентрации эстрадиола у женщин в сыворотке крови. Данный эффект обратим после отмены терапии. Вначале применения терапии на основе препарата Золадекс может провоцировать временное повышение концентрации тестостерона у мужчин в сыворотке крови и концентрации эстрадиола у женщин в сыворотке крови. На ранних стадиях терапии веществом у некоторых женщин могут отмечаться вагинальные кровотечения различной интенсивности и продолжительности.
У мужчин через 21 день с начала терапии гозерелином концентрация тестостерона уменьшается до кастрационных уровней и продолжает оставаться таковой при постоянном лечении, проводимом каждые 3 месяца с препаратом Золадекс 10,8 мг. Такое снижение концентрации тестостерона на фоне применения лекарства у большинства пациентов приводит к регрессии опухоли предстательной железы и к симптоматическому улучшению.
С начала введения первой капсулы препарата Золадекс в дозировке 10,8 мг концентрация эстрадиола в сыворотке у женщин снижается в течение 4 недель и, остается сниженной до уровня наблюдаемого у женщин в менопаузе. При изначальном введении других аналогов ГнРГ и переходе на препарат Золадекс 10,8 мг, снижение уровня эстрадиола сохраняется. Снижение уровня эстрадиола приводит к лечебному эффекту при фибромах матки и эндометриозе.
Может иметь место наступление менопаузы на фоне приёма агонистов ГнРГ. Восстановление менструаций после окончания терапии в редких случаях у некоторых женщин не происходит.
Фармакокинетика
Введение препарата Золадекс по 10,8 мг каждые двенадцать (12) недель создает поддержание стабильных высокоэффективных концентраций. Кумуляции в тканях при этом не происходит. Гозерелин плохо взаимодействует с белком, и период полувыведения его из сыворотки равно 2-4 часам у пациентов с нормальной функцией почек. Период полувыведения увеличивается у пациентов с нарушениями почечной функции. При ежемесячном введении препарата Золадекс по 10,8 мг данное изменение не будет иметь значительных последствий, поэтому не требуется изменять дозу для данных пациентов. У пациентов с печеночной недостаточностью не наблюдается значительных изменений в фармакокинетике.
Фармацевтические характеристики
Капсула для п/к введения пролонгированного действия из твердого полимерного материала, свободного или практически свободного от видимых включений, белого или почти белого со светло-коричневым оттенком цвета.
Упаковка, срок годности, условия хранения
Одна капсула по 10,8 мг для подкожного введения пролонгированного аппликаторе запакованная в шприц-аппликатор с защитной системой безопасного введения Safety Glide. Один шприц-аппликатор помещается в ламинированный алюминиевый конверт. Конверт с подвижно прикрепленным флажком-аннотацией помещается в картонную пачку с инструкцией по применению.
Хранить при температуре ниже 25° С. Хранить в местах, недоступных для детей.
Срок годности 3 года. Не применять по истечении срока годности, указанного на упаковке.
Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.
Заказать и купить Золадекс (Гозерелин) в Алматы
Заказать и купить Золадекс (Гозерелин) в Казахстане
Позвоните и узнайте цену Золадекс (Гозерелин)
Работаем и отправляем Золадекс (Гозерелин) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Золадекс (Гозерелин) по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.
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