Описание
Граноцит 34 (Granocyte 34) rHuG-CSF, рекомбинантный человеческий гликозилированный гранулоцитарный колониестимулирующий фактор) входящие в группу цитокинов — биологически активных белков, которые регулируют рост и дифференцирование клеток.
Использование Граноцита 34 у пациентов, получивших химиотерапию или подвергшихся трансплантации костного мозга, ведёт к значительному сокращению времени нейтропении и связанных с ней ухудшений.
Состав
- активное вещество — ленограстим (rHuG-CSF) 33,6 млн МЕ (263 мкг),
- вспомогательные вещества: D-маннитол, полисорбат-20,L-аргинин, L-фенилаланин, L-метионин, кислота хлористоводородная,
- растворитель – вода для инъекций.
Фармакодинамика
rHuG-CSF — фактор, стимулирующий клетки-предшественницы нейтрофилов костного мозга, показано, что в первые 24 часа после применения он создает заметное повышение числа нейтрофилов в периферической крови.
Данное увеличение числа нейтрофилов имеет дозозависимое течение в диапазоне от 1 до 10 мкг/кг/день. Повторное использование рекомендованных доз приводит к усиленной ответной реакции со стороны нейтрофилов. Производимые в ответ на Граноцит 34 нейтрофилы, характеризуются нормальными хемотаксическими и фагоцитарными функциями.
Подобно другим гемопоэтическим факторам роста, ленограстим in vitro производит активизирующее воздействие на эндотелиальные клетки.
Использование Граноцита 34 или в качестве монотерапии, или после химиотерапии мобилизует гемопоэтические клетки-предшественницы в крови. После высокодозовой цитотоксической химиотерапии аутологические клетки-предшественницы периферической крови (КППК) можно собрать и инфундировать, как в дополнение к пересадке костного мозга, так и вместо нее.
Произведенные в ходе мобилизации ленограстима, а затем инфундированные КППК способны восстанавливать гемопоэз и уменьшать срок приживления трансплантата, и в следствии чего сокращается число дней, необходимое для освобождения пациента от зависимости трансфузий тромбоцитов, если сравнивать с пересадкой аутологического костного мозга.
В подгруппе пациентов старше 55 лет положительный эффект от применения Граноцита34 проявился в ускорении восстановления числа нейтрофилов, увеличении процента больных безинфекционных периодов, сокращении периода госпитализации, продолжительности внутривенной антибиотической терапии и инфекционного периода. Однако эти положительные результаты не сопровождались уменьшением процента жизнеугрожающих или тяжёлых инфекций, ни снижением смертности, связанной с этими инфекциями.
Фармакокинетика
Фармакокинетика Граноцита 34 зависит от продолжительности приема и дозы препарата.
При повторном приеме препарата (инфузионно или подкожно) Cmax концентрация ленограстима в плазме крови соответственно введенной дозе; накопления ленограстима не выявлено. В рекомендуемых дозах абсолютная биодоступность ленограстима составляет 30%. Среднее время определения в организме при подкожном введении — 7 часов.
При подкожном введении период полувыведения ленограстима составляет приблизительно 3–4 часа, при внутривенном повторном ведении— 1–1,5 часа.
Граноцит 34 главным образом метаболизируется до пептидов и лишь в незначительной степени выводится с мочой в неизмененном виде (менее 1% введенной дозы). Существует прямая зависимость между дозой, между нейтрофильным ответом и концентрацией ленограстима в плазме.
Показания
препарата Граноцит 34
- сокращения времени нейтропении и связанных с ней ухудшений (у пациентов с не миелопролиферативными новообразованиями), которым проводилась миелосупрессивная химиотерапия с последующей пересадкой костного мозга и находящихся в группе повышенного риска развития продолжительной выраженной нейтропении;
- снижения длительности выраженной нейтропении и ухудшений с ней осложнений после стандартной миелосупрессивной химиотерапии;
- мобилизации периферических клеток-предшественников гемопоэза в периферической крови.
Фармацевтические характеристики
- Белый лиофилизированный порошок или масса.
- Растворитель — прозрачная бесцветная жидкость без запаха.
Упаковка, срок годности, условия хранения
Препарат помещают во флаконы из прозрачного и бесцветного стекла, закрытые резиновыми пробками, обжатые алюминиевыми колпачками с пластиковыми крышечками.
По одному мл растворителя помещают в стеклянные ампулы из прозрачного и бесцветного стекла.
По 5 ампул с растворителем и по 5 флаконов с препаратом помещают в пластиковый поддон. Каждый поддон вместе с инструкцией помещают в картонную коробку.
Хранить при температуре от +2°С до +25°С, в недоступном для детей месте. Стабильность Граноцита 34 не нарушается при кратковременном воздействии на флаконы температуры до +30°С (не более 14 дней). Не замораживать.
Срок годности: 2 года. Не применять по истечении срока годности.
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