Описание
Медицинский препарат Эстрацит (Estracyt) назначают при терапии карциномы предстательной железы. Эстрацит — это конъюгат эстрадиола и азотистого иприта, представляющий собой противоопухолевый препарат с двойным механизмом действия. Действующим веществом Эстрацита является эстрамустина фосфат, вещество принадлежащее к группе цитостатиков, Действие эстрамустина заключается в угнетении выработки половых гормонов и повреждении раковых клеток предстательной железы.
В большинстве случаев, рак предстательной железы протекает бессимптомно. Больше половины пациентов обращаются тогда, когда болезнь уже перешла на серьёзные стадии, когда первым признаком является боль в костях или суставах, когда уже имеют место различные метастазы.
Однако за последнее время смертность от рака предстательной железы значительно уменьшилась – благодаря эффективным программам лечения, где одну из существенных значений в положительной динамике отдано Эстрациту, который назначают в очень сложных ситуациях.
Состав
Одна капсула содержит:
- 156,7 мг моногидрата натриевой соли эстрамустина фосфата, что эквивалентно 140 мг эстрамустина,
- дополнительные вещества:натрия лаурилсульфат; тальк; стеарат магния; диоксид кремния коллоидный безводный;
- оболочка капсул: диоксид титана, желатин, чернила черные.
Один флакон порошка лиофилизированного для приготовления раствора для инъекций содержит:
- действующее вещество: эстрамустина фосфат 300 мг,
- вспомогательные вещества: меглумин; маннит
Показания препарата
- поздние стадии карциномы предстательной железы, особенно при рефрактерности к гормональной терапии;
- первичная терапия карциномы предстательной железы при наличии низкой эффективности гормональной терапии.
Фармакодинамика
Установлено, что в результате биотрансформации эстрамустина фосфата, получающиеся вещества эстрон и эстрадиол характеризуются антигонадотропной активностью и приводят к снижению уровня тестостерона. Эти метаболиты обладают антимитотическим действием, подавляя образование микротрубочек в метафазу и разрушая их в интерфазу митоза. В терапевтических дозах миелодепрессия проявляется слабо или практически отсутствует. Не оказывает иммунодепрессивного действия. Воздействет на переднюю долю гипофиза. Уменьшает продукцию гонадотропных гормонов, снижает концентрацию тестостерона в крови.
Фармакокинетика
Распределение и метаболизм
После в/в инфузии неизмененный эстрамустина фосфат обнаруживается в плазме, однако он быстро преобразуется с образованием эстрамустина, а затем — эстромустина, являющегося основным метаболитом в плазме. Связывание эстрамустина и эстромустина с белками плазмы высокое. Эстрамустин и эстромустин подвергаются дальнейшему преобразованию с образованием — эстрадиола и эстрона.
После введения препарата эстрамустин и эстромустин в основном обнаруживаются в опухолевой ткани предстательной железы человека. В опухолевой ткани концентрации эстрамустина и эстромустина выше, чем в плазме. Вероятно, потому что эстрамустин и эстромустин поглощаются тканью предстательной железы за счет их связывания со специфичным белком в опухолевой ткани предстательной железы.
Выведение
Эстрамустин и эстромустин выделяются с желчью и калом. Не обнаруживаются в моче.
Фармацевтическая характеристика
- Эстрацит выпускается в виде белых твердых желатиновых капсул по 140 мг, содержащих белый порошок. Капсулы размера 1, с черными надписями на крышке «ESTRACYT» и «К Ph 750» — на корпусе.
- Лиофилизированный порошок для приготовления раствора во флаконах по 300 мг. Растворитель (вода для инъекций) в ампулах по 8 мл. В коробке по 10 флаконов и по 10 ампул вместе с инструкцией.
Упаковка, срок годности, условия хранения
- По 40 или 100 капсул с осушителем во флаконах из темного стекла.
- Один флакон с инструкцией по применению в пачке картонной.
Хранить в недоступном для детей месте, при температуре не выше 25°C.
Срок годности — 3 года.
Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.
Заказать и купить Эстрацит (Эстрамустина фосфат) в Алматы
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Позвоните и узнайте ценуЭстрацит (Эстрамустина фосфат)
Работаем и отправляем Эстрацит (Эстрамустина фосфат) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также мы можем отправить Эстрацит (Эстрамустина фосфат) по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.
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In short, sensible growth—muscle sans body fat—is contingent on manipulating calorie consumption. Yes, you
must eat more to achieve mass, however if you eat more can decide whether
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Including a mass gainer shake aims to extend caloric intake by around 600 calories.
Monitor calorie consumption and exercise to avoid unwanted fat achieve.
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Protein is essential for mass features because it’s the only nutrient that’s capable of stimulating muscle growth.
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This increase in blood move to your muscle tissue has
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On your first three units, you do 8-10 reps, going as
heavy as you possibly can with proper type. Nevertheless, you’ll not lockout on the prime of each rep.
Locking out provides you with a mini pause at the high of every rep.
That isn’t what we want. Stopping just in want of
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Attack each exercise as if it have been crucial set of your life.
This is as a outcome of whey protein is
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These collectively together should keep a gradual supply of protein out
there to your physique for mass achieve (4). So, if you would like to full benefits of hitting your mass gain objectives, you want to make sure the caloric content
material of your mass gainer is excessive.
• Use as a recovery post-training drink and/or
complement with or between meals or as directed by your healthcare practitioner or health advisor.
NPL Hyper Gain is a mega calorie mass gainer for
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Regarding your protein intake, you must eat 1.6 grams per kilogram
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Prepare to maximise your features with our unique 12-week hypertrophy coaching program.
In addition, it’s also received tons in the greatest way of nutritional vitamins and minerals.
The core components are all the time high-energy
density meals, like starches and proteins, but completely different mass gaining dietary supplements
target totally different processes of the muscle gaining course of.
Many types of supplements claim to increase muscle mass, however there’s
little proof that they’re effective for healthy,
lively people. According to a 2017 evaluate of
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6 g of HMB per day can improve the gains in lean body mass from weight coaching.
Running a 5-day workout routine has many benefits if you do it properly.
Here are some reasons this might be the best program you ever run. And remember, don’t
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Simply stick to those fundamentals and visualize your self making features.
Anyone with well being conditions who may expertise worsening symptoms with further sugar in their food
plan need to contact a healthcare skilled before buying supplements.
Loop a thick towel around a barbell ensuring your palms are still able to utterly shut
when you grasp it. Holding the bar with an overhand,
shoulder width grip, place the bar in front of your thighs.
The extra lean tissue you’ve, the easier it is to stay lively and keep a healthy weight.
And the next body weight means you can eat extra calories
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for so much of. Whether Or Not you want to gain muscle mass to build on your physique or improve your well being, the duty of
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Do not fret about getting into a catabolic (muscle-wasting) state by not consuming each 2–3 hours.
This seemingly universal suggestion in bodybuilding is unnecessary, with sumo wrestlers being essentially the most muscular
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mass than pro bodybuilders. Though some folks suggest
consuming each few hours, doing so elevates the metabolism and will increase BMR (basal metabolic rate).
Thus, by consuming more frequently, you will want to devour larger portions of energy to achieve weight.
The major downside skinny guys face when bulking up is that their metabolism is already quick, so speeding this up further is counterproductive.
However that mentioned, supersets will solely work if you’re nonetheless pushing
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First off, research has proven that the nearer you train to failure,
the more development you’ll get but additionally the extra fatigue
you’ll create. Nevertheless, if you will go along with this
minimal volume, there are 3 things you have to start making use
of to your workouts to continue making almost as much or possibly
much more features than you had been before. This estimate is predicated on the ~3500 calories in a
single pound of fat.
You ought to consume as much as 2 grams of protein per pound of body weight day by
day. Consuming every three hours will help guarantee you’re absorbing and assimilating
enough protein to assist muscle growth. As it turns out, just about any kind of energy coaching can lead
to muscle development, since hypertrophy
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The longer and extra usually you’ll find a way to stress your muscles, the simpler your
hypertrophy coaching is.
On the contrary, some cardio is great for general health
advantages and may actually increase your muscle gains. You
enhance insulin sensitivity (more of the vitamins you eat get shuffled straight into your biceps) and
may eat more calories with out putting on physique fats.
Extra energy to play with means more power and vitamins in your muscle-building
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Monitoring weight, body composition, and power gains is essential for monitoring progress.
Common assessments of weight and power help
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A analysis evaluate found that combining creatine
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Dietary Supplements won’t save a poor food plan or
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Robust muscular tissues assist the bones, cut back the
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Right Here we share some foods you presumably can include to enhance muscle mass,
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She says you need to be intentional on not solely placing it on, but additionally maintaining it.
We all have fast-twitch and slow-twitch muscle fibers, however genetically some individuals could also be predisposed to have more of 1 than the opposite.
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Keep Away From mass gainers with artificial additives and excessive sugars to take care of digestive consolation.
How you construction your training, your selection of workouts, your food regimen, your
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Each phase is often a number of weeks long and allows
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so that your body never adapts and keeps rising. Pump coaching is outlined as high-volume training which causes sarcoplasmic hypertrophy,
a rise in sarcoplasmic fluid in your cells.
To construct muscle, you have to place enough stress in your muscles
to drive them to adapt; and lifting weights is the right resolution.
Have the program custom-made to your private needs with one of
our expert… This offering from Optimum Vitamin is
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This impact is identified as excess post-exercise oxygen consumption (EPOC).
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If you evaluate a pound of muscle to a pound of fats, you’ll see that muscle takes up much less area than fats.
This concept leads to confusion because of
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People with fast metabolisms might benefit significantly from mass gainers, as they help achieve the
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For best results, mass gainers ought to complement a balanced diet, not substitute meals.
They can provide round one thousand energy per serving,
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The No. 1 habit to interrupt if you’re trying
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Shoot for a high-quality protein source paired with
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