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Йонделис — Yondelis (Трабектедин)

Йонделис (Трабектедин)

Йонделис — Yondelis (Трабектедин)

Йонделис (Yondelis) — противораковый препарат. Применяется в лечебной терапии при прогрессирующей саркомы мягких тканей для пациентов, которые уже проходили лечение или не могут получать ифосфамид и антрациклиновую химиотерапию. Основное действующее вещество Трабектедин — это тристетрагидроизохинолиновый алкалоид природного (морского) происхождения. Препарат ингибирует транскрипцию генов и взаимодействует с системой репарации нуклеотидов. Это приводит к нарушению клеточного цикла. Трабектедин оказывает антипролиферативное действие in vitro и in vivo, включая рак молочной железы, саркому, немелкоклеточный рак легкого, меланому и рак яичников.

Категория:

Описание

Йонделис (Yondelis) — противораковый препарат. Применяется в лечебной терапии при прогрессирующей саркомы мягких тканей для пациентов, которые уже проходили лечение или не могут получать ифосфамид и антрациклиновую химиотерапию. Основное действующее вещество Трабектедин — это тристетрагидроизохинолиновый алкалоид природного (морского) происхождения. Препарат ингибирует транскрипцию генов и взаимодействует с системой репарации нуклеотидов. Это приводит к нарушению клеточного цикла. Трабектедин оказывает антипролиферативное действие in vitro и in vivo, включая рак молочной железы, саркому, немелкоклеточный рак легкого, меланому и рак яичников.

Состав

Каждый флакон содержит:

  • активное вещество: трабектедин 1 мг
  • вспомогательные вещества: сукроза (сахароза), калия фосфат однозамещенный, фосфорная кислота 0,1 N, калия гидроксид 0,1 М (для коррекции pH).

Показания препарата

  • рак яичников, рецидивирующий после терапии на основе производных платины;
  • саркома мягких тканей при нечувствительности к ифосфамиду и антрациклинам;

Фармакодинамика

Трабектедин связывается с малой бороздкой ДНК, в следствии чего спираль ДНК изгибается в сторону большой бороздки. Это запускает массу процессов, влияющих на факторы транскрипции ДНК и механизмы репарации ДНК, приводящих к нарушению клеточного цикла.

Фармакокинетика

После 24-часовой внутривенной инфузий уровень системного воздействия трабектедина пропорционален введенной дозе вплоть до дозы 1.8 мг/м2. Фармакокинетика трабектедина соответствует многокамерной модели распределения с периодом полувыведения в конечной фазе выведения 180 часов. Кумуляции вещества в плазме крови при введении 1 раз в 3 недели не выявлено.

связывается с белками плазмы; при концентрациях в плазме крови 10 и 100 нг/мл свободная фракция составляет соответственно 2.23% и 2.72%.

Распределение.

Трабектедин имеет большой объем распределения (> 5000 л), что соответствует широкому распределению по периферическим тканям. Трабектедин в довольно большой степени взаимодействует с альбуминами и кислыми альфа1-гликопротеинами плазмы крови. При концентрациях в плазме крови 10 и 100 нг/мл свободная фракция составляет соответственно 2,23 и 2,72%.

Метаболизм.

Трабектедин активно метаболизируется. Процесс его окисления осуществляется изоферментом CYP3A4, но не исключен факт участия и других изоферментов цитохрома в метаболизме трабектедина. Существенное глюкуронирование трабектедина не наблюдалось.

Выведение.

В неизмененном виде с мочой и калом выводится < 1%. Клиренс трабектедина в крови равен 35 л/час, что составляет примерно половину кровотока через печень человека. Значения клиренса трабектедина в плазме крови варьируют от 28% до 51%.

Особые группы пациентов

Фармакокинетика согласно данным популяционного анализа показывает, что клиренс трабектедина в плазме не зависит от возраста (19–83 года), массы тела (36–148 кг), пола и площади поверхности тела (0,9–2,8 м2) пациентов. Не выявлено расовых и этнических различий в фармакокинетике трабектедина.

Нарушение функции почек.

Нарушения функции почек не оказывают большого влияния на выведение трабектедина и его метаболитов.

Нарушение функции печени.

Введение трабектедина пациентам с дисфункцией печени показало, что нарушение работы печени ведет к усилению воздействия трабектедина. Необходимо внимательное наблюдение за токсичностью при использовании трабектедина у таких пациентов.

Фармацевтические характеристики

Лиофилизат для приготовления раствора. Порошок белого или почти белого цвета.

Упаковка, срок годности, условия хранения

По 428.2 мг лиофилизата помещают во флаконы бесцветного прозрачного стекла объемом по 25 мл, закупоренные пробками из бромбутилового эластомера и обкатанные алюминиевыми колпачками с крышками «flip-off».

Флаконы стеклянные (1) — пачки картонные. По 1 флакону вместе с инструкцией по применению помещают в картонную пачку /в пачку из картона.

Хранить при температуре от 2 °С до 8 °С. Раствор следует разбавить и использовать немедленно.

Хранить в недоступном для детей месте!

Срок хранения 3 года. Не применять после истечения срока годности.

 

 

 

 

Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.

Заказать и купить Йонделис (Трабектедин) в Алматы

Заказать и купить Йонделис (Трабектедин) в Казахстане

Позвоните и узнайте цену Йонделис (Трабектедин)

Работаем и отправляем Йонделис (Трабектедин) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Йонделис (Трабектедин) по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.

Детали

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Великобритания

Тип

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    The leg press machine features a moveable platform
    that you push away out of your physique with your legs.
    Most industrial health club leg press machines are angled at 45 levels, although your gym may have machines that
    require you to push horizontally or vertically.
    If you used each leg machine at your health club, your exercise would be far too long, and also you’d end up overtraining your
    lower physique. That Is why it’s essential to have the ability to identify the
    machines that will provide one of the best bang in your buck when it comes to strength and muscle gain.
    VASA Health is right here to help your health journey with state-of-the-art tools, spacious facilities, and skilled steering.
    Working out on leg machines is a great way to construct muscle within the legs and even get a greater booty.

    You’re unsupported, lifting up and down in your toes to interact the calf
    muscle. Each variations of the exercise goal to focus on the muscles behind the lower leg.
    The hack squat machine engages fewer muscular tissues than the regular squat.
    So, you’ll be capable of raise more than you’d when it’s simply you and a barbell.
    It’s suitable for those trying to the motion and
    to focus on the quads and hamstrings a little higher.
    If you’ve injured your hamstring, you’re in for a protracted restoration. Leg curl machines offer you managed actions that won’t jerk your muscle tissue and ligaments around.

    The second day of the workout plan will give attention to pulling muscles in our upper bodies like the back and biceps.

    But they are also scientifically backed to enhance your efficiency and power gains considerably.

    So, there’s little to no probability of sustaining any accidents or overtraining whereas following our machine-only push-pull legs break up training
    routine. Studies have proven that in relation to power, training wherever between 2
    and 6 days per week may be effective as lengthy as the workout plan is well-balanced and stimulating
    sufficient [2].
    The American College of Sports Drugs found that resistance coaching is
    typically recommended to reduce the rate or severity of musculoskeletal injuries.
    Subsequent, evidence signifies that working out your legs can enhance a point of pain in your decrease back.

    If you need to crush PRs, add slabs of muscle, or lose weight, KIZEN has the perfect program for
    you. The posterior (plantar flexor) group are muscular tissues located at the again of your leg that help
    in maintaining your toes pointed downward (plantar flexion) on the ankle joint.

    Doing so will allow you to continue adding quantity to your quadriceps and different leg press muscular tissues worked without inflicting the extra fatigue that loading
    a barbell on your spine creates. One benefit of the leg press machine is you could
    emphasize different muscles by varying your leg press foot place.
    It builds energy in these muscular tissues, and you need to use it to beat imbalances,
    similar to overly developed hamstrings, compared to
    quadriceps. Coaching each muscle becomes crucial to building a stable decrease
    physique. The Smith machine is amongst the best health club gear for successfully strengthening quads, hamstrings,
    glutes, and calves. The fitness center is tailored to cater to people with diverse fitness targets and will hit all the main muscle teams.

    «Adjust the Smith machine’s safety pins to waist peak whereas performing this exercise,» says Saini.
    It makes the exercise safer and gives you the boldness
    to raise somewhat heavier. You can replicate this exercise utilizing
    your trusty Smith machine. Each novices and advanced lifters can tremendously benefit from performing deadlifts 1
    to three times per week. This exercise additionally targets different
    muscle groups, which include the again,
    traps, and core.
    Then, by urgent towards a foot plate, the user performs a squat
    motion. There is not any higher train than the leg extension to isolate
    the quadriceps. The only movement involved is knee extension, which is the primary function of the quads.
    Generally you don’t have the luxury of free weights to do a leg workout,
    other times you just don’t feel like it. If that’s you
    proper now – then that is our information to one of the best machine solely leg exercise.
    I am totally aware that operation of health club amenities and participation in physical
    activity could additionally be harmful and involves risk of damage to my individual.

    This leg machine is amongst the greatest leg machines for working quads.
    This machine comes with built-in again help, making it probably the greatest leg machines on our record.

    The design permits you to keep spinal alignment which reduces the chance of injury.
    Examine out our article about the comparability between the
    hack squat and leg press to add more data to your subsequent workout session. I would
    suggest, when doing calves, to not do lower than 20 reps each working set.
    The gastrocnemius is the distinguished calf muscle, while the soleus sits
    beneath.
    These muscles are pivotal for actions like strolling,
    operating, and sustaining steadiness. Constructing strong calves not only improves athletic prowess but additionally supplies essential ankle stability.
    The volume of your workout program refers to the number of sets, reps, and
    workouts carried out in each workout. If you don’t have
    a platform to perform the standing cable one-leg calf elevate from, you can do it on the ground.

    It’s an unconventional motion, however it’s very effective for constructing the lower posterior chain muscular tissues.
    The cable standing leg curl is helpful when you can’t entry a leg curl machine.

    Let’s check out a few rules in your journey to larger legs with out machines and then we’ll take a glance at a program to get you started.
    Clients have different views on the exercise machine’s construct quality.

    Some discover it well-made and helpful for circulation and leg
    energy, whereas others point out points with durability, low-cost plastic materials, and wheels breaking
    down easily.
    This versatility is ideal for comprehensive leg exercises, as you can target the legs from numerous angles and with different intensities.
    The muscles in the calves are needed for many different actions.
    Generally, they lag behind when it comes to power compared to the quads or the hamstrings.

    The intuitive design, fastened path of movement, and typically printed
    instructions of machines might help users give consideration to
    correct type fairly easily. The Smith machine is extremely versatile and whilst not specifically
    a leg machine, you could use it as a one-stop store on your subsequent leg day.
    You may even grab a bench and set up for hip thrusts, lunges, standing calf raises–the record goes on. If you’re new to
    energy training, the leg extension machine is a good place to start out as a end result of it has a simple setup.
    This is a seated train the place a weighted pad rests on the highest of
    the decrease legs, beginning with the knees bent at 90
    levels. The primary benefit of the leg extension machine
    is to isolate the quadriceps.
    It permits you to do myriad workout routines for every
    muscle and helps increase strength, endurance, and mass. In this text, I’ll share various Smith machine exercises
    for every muscle group. This is a full body exercise
    so that you just can hit all of your muscle groups in one
    health club session… discuss getting probably the most bang
    in your buck.
    Free weights provide a wider range of motion but additionally demand more steadiness and stabilization from the consumer.
    Higher muscular growth and definition can result from this and an enchancment in general energy and steadiness.
    Free weights are additionally extra adaptable, enabling a broad range of exercises that can target totally
    different muscle groups.
    By using a half rack for your squats you’ll be steady in your setup and safe should you
    drop the burden. Make certain that the bench is about to a
    steep angle in order to isolate the glutes.
    As it gets easier, you could make it tougher by including one other rep every session and/or lowering your rest intervals.
    Kneeling cable kickbacks particularly target the gluteus maximus whereas using the
    hamstrings as the accent muscle group. This exercise is great for activating the upper-back
    muscles – the rhomboids and the traps. For triceps brachii, we now have two exercises – single-arm cable
    tricep pushdowns and bent-over cable tricep kickbacks.

    So we put our heads collectively and examined out a couple of great machine solely leg exercises, so we are by
    no means left disenchanted once more. Many opt for leg exercise
    machines to simplify leg day, streamlining their routines.
    The leg press machine, a well-liked piece of fitness
    center equipment, targets and strengthens many leg muscular tissues.

    It includes a 45-degree reclined seat with a platform
    on your ft and an adjustable weighted sled. The cable leg workout routines are divided into
    squats, cable deadlifts, cable lunges, and calf raises.
    This is the train that is deemed most effective for focusing
    on solely the stomach muscular tissues. But since you’re only utilizing machines to work out, your core
    might be lacking in strength as well. Our machine-only PPL workout plan includes
    easy workouts that yield the most efficient outcomes.
    The chest press, as an example, is the best train for constructing
    your chest muscles.
    These machines hit the internal and outer thigh, the muscular tissues which are important for
    hip stability and everyday actions. Since the movements
    on the hip abduction/adduction machine are sluggish and controlled there could
    be less chance of causing harm to the targeted and surrounding muscle tissue.
    Since you’re sitting down, there is also a lower chance of any decrease again points.

    Inserting your feet lower on the footplate will emphasize the quads extra,
    however this also places extra stress on the knees and ought to be done with caution. If your
    buttocks are raised off the seat, your legs are at too sharp
    of an angle. You might want to move the seat again until your knees and buttocks are
    comfortably positioned. You can recognize poor positioning if you feel cramped, and/or
    your knees appear to be immediately in front of your eyes.
    Additionally, the leg press could be safer at high volumes of weight or reps, which we are
    going to discuss shortly.
    Except you choose the right leg machine, you’re probably going to end up with less-than-ideal results.
    To put extra about what this train can do for you, learn our article on belt squats.

    The gym is our go to hotel filter and we once did 10,000 steps on a flight to LA.
    Solely when you’ve adopted those steps above, have you actually failed, and for this reason ‘1 working
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    but merely elevate and lower in that place. If you’re
    seeking to burn some calories, treadmills are a great way to shred those
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