Описание
Препарат Вистид — противовирусный препарат, используемым в терапии больных СПИДом, который главным образом, применяется для лечения цитомегаловирусного ретинита (инфекции сетчатки глаза). Главный компонент препарата — Цидофовир, характеризуется способностью попадать в ДНК цитомегаловируса, тем самым подавляя скорость ее репликации. Оказываемый препаратом избирательный эффект останавливает синтез клеток вируса, которому часто подвергаются люди с ослабленным иммунитетом, особенно больные СПИДом.
Несмотря на множество испытаний лекарства для терапии разных заболеваний, единственным признанным во всем мире предназначением Цидофовира стала терапия цитомегаловирусного ретинита у больных СПИДом. Цидофовир втраивается в удлиняющуюся цепь ДНК вируса и блокирует вирусную ДНК-полимеразу. В результате замещения активного вещества нативным субстратом dCTP репликация ДНК снижается и процесс копирования вируса разрушается.
Препарат Вистид может использоваться для борьбы с разными типами герпесвируса, в том числе с вирусами полиомы, аденовирусами и папилломы. Препарат рекомендован для лечения ЦМВ-ретинита у больных с синдромом иммунодефицита человека. Цидофовир используется и при иных видах инфекции цитомегаловируса, в том числе для местной терапии поверхности тела, инъекционно (внутримышечно) – если у человека обнаружен папилломатоз гортани и пищевода, вводят внутривенно в течении лечения мультифокальной лейкоэнцефалопатии.
Показания к применению
- Впервые Вистид начали использовать в 1996 году при лечении цитомегаловируса у СПИД-положительных пациентов. На сегодняшний день Вистид показал ингибирующую активность в отношении всех вирусов герпеса и официально используется при лечении цитомегаловирусного ретинита у пациентов со СПИДом.
Фармакодинамика
Препарат Вистид — синтетическое лекарство из класса нуклеозидных аналогов, разработанный против раковых заболеваний, успешно ликвидирует злокачественные образования. Основные компоненты, входящие в состав, помогают росту метаболита — цидофовир дифосфат, который тормозит быстроту химической деятельности из ДНК-полимеразы. В том числе данный метаболит останавливает выработку злокачественной ДНК и срока элонгации. Проявляет результативность в отношении всех вирусов герпеса и других ДНК-содержащих вирусов Активен к таким вирусам, как цитомегаловирус; герпес 6 или 8 типа; вирус папилломы человека; инфекция с пузырьковой сыпью; Эпштейн-Барр.
Активен в отношении вируса Varicella zoster, цитомегаловируса, вируса Эпштейна-Барр, ВГЧ-6, ВГЧ-8; менее активен против вируса простого герпеса. Устойчивые к ганцикловиру, штаммы цитомегаловируса, обычно чувствительны к цидофовиру. Цидофовир-устойчивые штаммы обычно резистетны к ганцикловиру и восприимчивы к фоскарнету. Вирус простого герпеса, устойчивый к ацикловиру, часто оказывается восприимчив к цидофовиру.
Цидофовир также продемонстрировал эффективность в лечении ацикловира устойчивыми HSV инфекций. Цидофовир также изучался как средство лечения возрастающей мультифокальной лейкоэнцефалопатии с успешными отчетами о его использовании. Несмотря на это, препарат не проявил какой-либо результативности в контролируемых исследованиях.
Цидофовир — обладает активностью in vitro против следующих вирусов: Герпесвирусы человека Аденовирусы Поксвирусы человека (включая вирус оспы ) Вирус папилломы человека. Цидофовир могут иметь эффективность анти оспы и может быть использован на ограниченной основе в случае Биотеррористического инцидента с участием случаев оспы. Разработан бринцидофовир — производное цидофовира с гораздо более высокой активностью против оспы, которое можно перорально принимать. Он оказывает ингибирующее действие на синтез вируса ветряной оспы in vitro, хотя до настоящего времени не проводилось клинических испытаний, возможно, из-за большого численности более безопасных альтернатив, таких как ацикловир. Против вируса ВК в подгруппе реципиентов трансплантата цидофовир проявляет активность. Исследуется цидофовир в качестве дополнительной терапии внутри очага поражения против папилломатоза, вызванного ВПЧ.
Фармакокинетика
Биодоступность
Цидофовир характеризуется низкой оральной биодоступностью (всего лишь 5%), поэтому выпускают его в виде раствора для внутривенного введения. Цидофовир активно проникает во все ткани организма, за исключением глаз и спинномозговой жидкости. Осуществление выведения происходит через почки путем клубочковой фильтрации, почечных каналец. Yеобходимо внутривенное введение; пробенецид повышает AUC на 40-60 процентов, преимущественно за счет блокады канальцевой секреции цидофовира. В СМЖ не определяется.
При попадании в организм он быстро распространяется по всему телу. При внутривенном вливании период полувыведения составляет около трех часов.
Выведение
Выводится главным образом через почки. 70-85 процентов активного вещества выводится с мочой. Период полувыведения активного внутриклеточного метаболита составляет 17-65 часов. Это позволяет делать длительные перерывы между введениями очередных доз лекарства.
Возможные побочные эффекты
Перед покупкой препарата Вистид, следует проконсультироваться с лечащим врачом относительно возможных нежелательных реакций, обычно оказываемые данным препаратом на организм. Вистид показал себя как высокотоксичное лекарство, которое следует принимать одновременно с другими препаратами, ослабляющими нежелательные проявления. Согласно исследованиям, препарат обладает повышенной эмбриотоксичностью, мутагенностью, тератогенностью, гонадотоксичностью и канцерогенностью, а также нефротоксичностью. Во многих случаях цена за возможность пользоваться лекарством сводится к возникновению:
- Протеинурии (определение белка в моче).
- Нейтропении.
- Пониженного внутриглазного давления.
- Переднего увеита (глазная патология).
- Лихорадочного состояния.
- Рвоты.
- Диареи.
- Кожных высыпаний.
- Выпадения волос.
Особенные предупреждения
Перед началом приема Вистида необходимо сообщить врачу об уже используемых препаратах, аллергических реакциях, пищевых добавках, существующих заболеваниях и текущем состоянии здоровья.
Случаи острой почечной недостаточности имели место в одном или двух случаях применения цидофовира. В течение 48 часов до введения каждой дозы цидофовира следует проверять функцию почек (сывороточный креатинин, электролиты, протеинурия).
Нейтропения может развиваться во время терапии цидофовиром. Для контроля развития нейтропении необходимо регулярно определять количество нейтрофилов.
Вистид нельзя принимать одновременно с лекарствами, которые способны усиливать его нефротоксичность. С момента окончания приема какого-либо нефротоксичного лекарства до начала курса лечения цидофовиром должно пройти не менее одной недели.
На время лечения необходимо отказаться от управления автомобилем и работы с другими механизмами.
Фармацевтические характеристики
Вистид выпускается в виде раствора, предназначенного для внутривенных инъекций.
Упаковка, срок годности, условия хранения
В одном флаконе, объемом 5 мл, содержится 375 мг цидофовира. Флаконы упакованы в картонную пачку по одной штуке. Он выпускается в виде раствора с дозировкой 375 мг/5 мл.
Хранить в сухом, темном месте, расположенном как можно дальше от детей, животных. Хранить можно в течение 2 лет с момента выпуска при нормальной комнатной температуре в оригинальной упаковке. Не используйте просроченное средство.
Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.
Заказать и купить Вистид (Цидофовир) в Алматы
Заказать и купить Вистид (Цидофовир) в Казахстане
Позвоните и узнайте цену Вистид (Цидофовир)
Работаем и отправляем Вистид (Цидофовир) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Вистид (Цидофовир) по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.
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