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Онкаспар — Oncaspar (Пэгаспаргаза 3750Е)

Онкаспар (Oncaspar) Пэгаспаргаза (Pegaspargase) 3750Е Австрия

Онкаспар — Oncaspar (Пэгаспаргаза 3750Е)

Компания Medical&Pharma предлагает современное противолейкозное лекарство — Онкаспар (Пэгаспаргаза). С действующим веществом Пэгаспаргаза. Лекарственное средство используется для лечения злокачественных новообразований. Онкаспар – препарат, имеющий цитостатические свойства, используется и в случаях повышения чувствительности к L-аспарагиназе в наитивной форме, у детей и у взрослых пациентов. Способен нарушать процесс синтеза белка в структурах РНК и ДНК, подавлять деление клеток, тем самым препятствовать опухоли распространяться по организму.

Категория:

Описание

Компания Medical&Pharma предлагает современное противолейкозное лекарство — Онкаспар (Пэгаспаргаза). С действующим веществом Пэгаспаргаза. Лекарственное средство используется для лечения злокачественных новообразований. Онкаспар – препарат, имеющий цитостатические свойства, используется и в случаях повышения чувствительности к L-аспарагиназе в наитивной форме, у детей и у взрослых пациентов. Способен нарушать процесс синтеза белка в структурах РНК и ДНК, подавлять деление клеток, тем самым препятствовать опухоли распространяться по организму.

Состав

  • Пэгаспаргаза, раствор для инъекций 3750 МЕ флакон 5 мл, № 1. В соответствии с рекомендациями Международного Биохимического Союза Активность Онкаспара выражается в международных единицах (МЕ), где один МЕ L-аспарагиназы определяется как количество фермента, требуемое для образования одного мкмоль аммония/мин при температуре 37С. и рН 7.3.
  • Прочие ингредиенты: натрия дигидрофосфат, натрия хлорид, натрия гидрофосфат, вода для инъекций.

Показания

Онкаспар показан в качестве компонента антинеопластической комбинированной терапии в комбинации с другими противоопухолевыми препаратами для для реиндукции ремиссии острого лимфобластного лейкоза у взрослых и детей при наличии у них повышенной чувствительности к нативным формам фермента L-аспарагиназы.

Фармакодинамика

Пэгаспаргаза – фермент L-аспарагиназа, синтезируемой микроорганизмом E.Coli, модифицированная путем ковалентного связывания с монометоксиполиэтиленгликолем (PEG). L-аспарагиназа катализирует расщепление аминокислоты аспарагина, которая необходим для жизнедеятельности клеток, в плазме крови. Считается, что противоопухолевое действие препарата обусловлено снижением уровня аспарагина в лейкемических опухолевых клетках, которые в отличие от нормальных клеток, вследствие отсутствия аспарагинсинтетазы, не способны синтезировать собственный аспарагин . В результате нарушается синтез белка, а также синтез ДНК и РНК, и тем самым идет гибель опухолевых клеток.

Фармакокинетика

Пик концентрации пэгаспаргазы в плазме крови после внутривенного введения были пропорциональны введенной дозе. Объем распределения эквивалентен объему плазмы. Период полувыведения пэгаспаргазы при в/в введении в плазме крови составляет в среднем 10.5 дней, и он не зависит от дозы, кратности введений, диагноза и тяжести заболевания, площадь поверхности тела, функции печени и почек, возраста, пола. После окончании одночасовой внутривенной инфузии пэгаспаргазы аминокислота L-аспарагин в плазме крови не обнаруживается. Однако, значения L-аспарагиназы, доступные для определения, сохраняются в плазме в течение как минимум 15 дней после первого введения вещества (в течение 15 дней после первого введения Онкоспара измеряли уровень L-аспарагиназы в плазме)
Путь выведения препарата не установлен. Фермент не определяется в моче.

Фармацевтические характеристики

Раствор для в/в и в/м введения прозрачный, бесцветный или слегка опалесцирующий.

Упаковка, срок годности,
условия хранения

5 мл — флаконы (1) — пачки картонные.
Хранить в недоступном для детей месте, в холодильнике (2–8 °С). Не замораживать. НЕ ВСТРЯХИВАТЬ! Неиспользованные остатки необходимо уничтожить.

Не использовать: если он хранился более 48 ч при комнатной температуре; если раствор стал непрозрачным; при возникновении осадка.

 

 

 

 

Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.

Заказать и купить  Онкаспар (Пэгаспаргаза) в Алматы

Заказать и купить Онкаспар (Пэгаспаргаза) в Казахстане

Позвоните и узнайте цену Онкаспар (Пэгаспаргаза)

Работаем и отправляем Онкаспар (Пэгаспаргаза 3750Е) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Онкаспар (Пэгаспаргаза 3750Е)  по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.

 

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    the entire body should embrace workout routines that target the main muscle
    groups of the body. It also wants to incorporate all seven motion patterns — squat, push, pull, hinge,
    lunge, rotate and carry. You probably already know that lifting weights may help you construct muscle and
    strength, but you is probably not aware of the significance of working out completely different muscle teams together.

    When you work out, your muscular tissues need time to get well between sets.
    By working for various muscle groups together, you give each group the time it must get
    well while still getting an excellent exercise.

    For example, you might do a set of chest presses adopted by a set of bicep curls.

    After studying this text, you could be excited on the prospect of remodeling your physique and fulfilling your genetic potential.
    And to attempt this, you need coaching, diet, and mindset to be aligned.
    This permits me to train the muscle group from multiple angles but in addition in a means
    in order that my higher pec isn’t fatigued from the prior
    session and I can go full gasoline. Spreading that volume over the week offers you the chance to make each on of those units depend.
    I’ll brazenly admit this may be a bit anecdotal and primarily
    based on my experience, but I believe it has merit. You have a job,
    a profession, probably a family, and also you even might need
    a social life. Giving all that as a lot as go train in the gym twice
    a day, every day of the week probably isn’t
    going to happen.
    It’s essential to mix up your workouts and
    goal totally different muscular tissues in every session, as this can help you build
    energy and avoid overtraining any one area. Training three days every week creates loads of time to recover from the
    exercises. Additionally, because you’re not within the gym as much, you will
    not waste time on fluff; you may merely concentrate in your major movements.

    You could even alternate between a heavy day, a light day and
    somewhere in between, for every totally different muscle-group.

    For instance, you can focus on heavy lifting for your chest and shoulders in one session whereas
    keeping it light on your legs and back. Then, on the following day, swap it up with
    heavy squats and lighter work for your upper body.

    Use flyes at any level in your exercise or initially
    to pre-exhaust your chest before you hit the bench. Prioritizing your pecs is step one in boosting pec positive aspects.
    Instructor Ben Alldis shares his tips for reaching well-rounded energy training.
    The idea of restoration is easy and simple, however for a lot of people, it’s exhausting to observe via.

    Coaching a quantity of muscle groups in the identical session isn’t
    just convenient—it’s a smart approach to improve your general fitness.
    This break up allows you more time with each muscle group, and lets
    you go exhausting on accent motions. «Your first obligation in your coaching is to all the time prepare those larger main muscle groups,» Samuel says.

    «In half as a end result of if we try this well, we’ll tangentially train our secondary muscle groups and our minor muscle groups.» It helps to
    guarantee that all the muscular tissues are getting a good workout and that they’re being labored
    in stability with each other. On the other hand, if
    you are on the lookout for extra endurance-based outcomes,
    one or two classes per week may suffice.

    Analysis varies broadly on the method to group your muscles
    collectively and organize exercises all through the week.
    With this information, you possibly can create exercise variations
    or alternative workout routines that work the same muscular
    tissues whereas achieving your desired consequence. Creating a practical workout routine is
    all about finding the proper stability between muscle teams.
    It is crucial to perform these workout routines slowly and carefully for
    optimum benefit with out risking damage; specializing in correct kind
    quite than velocity will be useful. The rhomboids are two small diamond-shaped muscle tissue between your shoulder blades
    that assist pull them together if you squeeze them.
    The anatomy of the again muscles consists of a
    number of major muscle groups.
    That’s with the same variety of units accomplished for upper and lower body — meaning
    the upper-lower cut up workouts have been shorter however
    extra frequent. Combining particular muscular tissues into workout teams helps hold additional
    blood flowing to the same space of the physique as you train, according to Carolina Araujo,
    CPT, a California-based strength coach. This encourages muscle development and can make your
    workouts more efficient — significantly should
    you’re within the fitness center and have to transition between different gear.
    If your goal is energy, focus on compound movements with complementary muscles, like
    squats paired with shoulder presses or deadlifts with pull-ups.
    If you presumably can supplement this coaching with some at-home body weight training throughout the week, you should contemplate
    it.
    To successfully construct muscle, it’s important to prioritize
    recovery by way of adequate sleep and correct vitamin. The 
    overhead press has earned its place in any good push pull workout routine by being top-of-the-line workouts you can do to strengthen your higher physique muscle tissue.
    In this article, you’ll discover one of the best push pull cut up and learn how it
    can help you attain your health goals and construct muscle and power faster than you thought possible.

    We’ll discuss a few of these and the way varied training variables can be built-in into this program.
    The lying bench hip rollup strengthens your deep
    core muscles—the transverse abdominis and obliques—says Ron Mathews,
    coach to celebs like Joe Manganiello and Hugh Jackman. The two main capabilities of those muscles are pulling the ribs down and stabilizing
    the backbone. Because in case your rib cage raises, it forces your back to arch
    excessively, which isn’t environment friendly for transferring force and can lead to
    harm. Strengthening these muscle tissue will assist your posture, protect your again, and decrease misplaced force throughout the core.

    Individualization – even the best cookie-cutter applications are
    geared toward populations and not people. Writing your own exercises
    means that every thing you do will match your wants and targets.

    Supersetting bicep curls with tricep pushdowns keeps the arms in constant motion, resulting in a
    extra significant muscle pump and higher general fatigue.

    The chest handles pushing motions, while
    the back is responsible for pulling. By tailoring your pairings to
    your aims, you also can make each exercise session a step closer
    to reaching your targets. The key is to acknowledge and leverage these pure synergies to
    make your sessions more practical with out overcomplicating
    your routine.
    Regularly check your targets and modify your cut up to keep enhancing.

    Stability muscle groups, permit sufficient restoration, and mix compound and isolation exercises.
    Novices discover a 3-day cut up great for structured training and
    recovery.
    If you resolve to go for a 5 day split and you are feeling fatigued after a
    couple weeks, place a relaxation day in-between each 2 exercise classes.
    It’s nice if you complete your split routine in 8
    or 9 days rather than 7. Most individuals do completely
    nice with a 5 day exercise as a outcome of the exercises
    are so centered on one space of your physique and there’s
    plenty of restoration, so it’s onerous to overtrain.
    So, you are looking at round minutes per workout, not including heat up and cool down. It’s
    essential to remember; you can have the right programme, but a perfect programme by no means completed
    is rendered ineffective. So, choose a exercise frequency that fit your expertise, preferences
    and time constraints so as to push yourself in your workouts,
    recuperate properly and get results. Training sessions needn’t be hours lengthy both to see benefits.
    Whether you’re utilizing bodyweight workout routines
    or weights, full body workouts are versatile and efficient.
    Squat workout routines just like the back squat and the front squat contain the hip, knee, and ankle joints and recruit a number of
    main muscle teams within the decrease body.
    Muscular Tissues require both exercise and rest to totally function and generate energy.
    Many giant muscle group exercises are thought of compound workouts, named so as a result of they also engage
    the big muscles’ complementary muscle groups together with multiple joints.

    Meaning, all pushing muscular tissues on the same day,
    then all pulling muscle tissue.
    When it involves performing a full-body exercise, are
    we really hitting each necessary moves? There’s a slight chance that in our seek for creating the simplest workout
    in the shortest amount of time, effectiveness at instances gets sacrificed for effectivity.

    The face pull is an incredible exercise to strengthen your posterior deltoids, higher trapezius, and rotator cuff muscle tissue.

    This is called periodization and it’s important to avoiding overtraining, it would not matter what health stage you’re.
    You can even design a strength coaching program, by pairing muscles by opposing pressure.
    Opposing muscle tissue, also known as «antagonists» may be considered anterior and posterior
    of one another based on their anatomical positioning.

    With an additional day of training to play with, you can even get extra artistic with your workouts, including
    in some extra selection, or alternating between heavy weight and high rep days.

    Regardless, due to its nature, a bro break up requires a high training frequency to train every body part weekly.
    The bent-over barbell row works lots of the antagonists of the bench press exercise, and is beneficial
    for evening out the power and muscle stability across your higher
    physique. Now that you know which muscle groups to work
    out collectively, you might want slightly guidance getting began.
    The extra you split up and isolate the muscular tissues
    as the primary focus for every workout, the much less relaxation days you’ll doubtless have to take.
    The more muscle tissue worked in every workout, such as a full physique workout, the extra rest days you’ll likely
    need. If you do not plan accordingly, and select to train your arms and shoulders the next day …
    This can enhance your threat of damage and hinder your restoration. So
    if you’re coaching three days per week, coaching a single muscle group per session makes very little sense.

    And particularly whether or not or not you need to prepare muscle groups as
    soon as a week, or a quantity of occasions in a
    7 day interval. This technique divides workouts into classes that target muscles involved in pushing actions and those concerned in pulling movements.
    One Other boon of the standing cable chest fly is that it’s easy to maintain constant
    tension on the muscular tissues throughout the whole
    vary of movement. Properly, that is a tiny muscle, situated beneath your
    pectoralis main. It originates from your high 2–4 ribs and inserts
    on the coracoid process in your scapula. Its main capabilities are to protract your scapula and rotate your scapula forward.
    In phrases of chest hypertrophy and power training, the pectoralis minor is often negligible,
    and likewise often skilled by comparable workouts as your pectoralis
    main anyway.

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