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с 8:00 до 22:00
Казахстан, г. Алматы
ул. Аскарова, 10, 3-этаж
Обратная связь

Онкаспар — Oncaspar (Пэгаспаргаза 3750Е)

Онкаспар — Oncaspar (Пэгаспаргаза 3750Е)

Компания Medical&Pharma предлагает современное противолейкозное лекарство — Онкаспар (Пэгаспаргаза). С действующим веществом Пэгаспаргаза. Лекарственное средство используется для лечения злокачественных новообразований. Онкаспар – препарат, имеющий цитостатические свойства, используется и в случаях повышения чувствительности к L-аспарагиназе в наитивной форме, у детей и у взрослых пациентов. Способен нарушать процесс синтеза белка в структурах РНК и ДНК, подавлять деление клеток, тем самым препятствовать опухоли распространяться по организму.

Описание

Компания Medical&Pharma предлагает современное противолейкозное лекарство — Онкаспар (Пэгаспаргаза). С действующим веществом Пэгаспаргаза. Лекарственное средство используется для лечения злокачественных новообразований. Онкаспар – препарат, имеющий цитостатические свойства, используется и в случаях повышения чувствительности к L-аспарагиназе в наитивной форме, у детей и у взрослых пациентов. Способен нарушать процесс синтеза белка в структурах РНК и ДНК, подавлять деление клеток, тем самым препятствовать опухоли распространяться по организму.

Состав

  • Пэгаспаргаза, раствор для инъекций 3750 МЕ флакон 5 мл, № 1. В соответствии с рекомендациями Международного Биохимического Союза Активность Онкаспара выражается в международных единицах (МЕ), где один МЕ L-аспарагиназы определяется как количество фермента, требуемое для образования одного мкмоль аммония/мин при температуре 37С. и рН 7.3.
  • Прочие ингредиенты: натрия дигидрофосфат, натрия хлорид, натрия гидрофосфат, вода для инъекций.

Показания

Онкаспар показан в качестве компонента антинеопластической комбинированной терапии в комбинации с другими противоопухолевыми препаратами для для реиндукции ремиссии острого лимфобластного лейкоза у взрослых и детей при наличии у них повышенной чувствительности к нативным формам фермента L-аспарагиназы.

Фармакодинамика

Пэгаспаргаза – фермент L-аспарагиназа, синтезируемой микроорганизмом E.Coli, модифицированная путем ковалентного связывания с монометоксиполиэтиленгликолем (PEG). L-аспарагиназа катализирует расщепление аминокислоты аспарагина, которая необходим для жизнедеятельности клеток, в плазме крови. Считается, что противоопухолевое действие препарата обусловлено снижением уровня аспарагина в лейкемических опухолевых клетках, которые в отличие от нормальных клеток, вследствие отсутствия аспарагинсинтетазы, не способны синтезировать собственный аспарагин . В результате нарушается синтез белка, а также синтез ДНК и РНК, и тем самым идет гибель опухолевых клеток.

Фармакокинетика

Пик концентрации пэгаспаргазы в плазме крови после внутривенного введения были пропорциональны введенной дозе. Объем распределения эквивалентен объему плазмы. Период полувыведения пэгаспаргазы при в/в введении в плазме крови составляет в среднем 10.5 дней, и он не зависит от дозы, кратности введений, диагноза и тяжести заболевания, площадь поверхности тела, функции печени и почек, возраста, пола. После окончании одночасовой внутривенной инфузии пэгаспаргазы аминокислота L-аспарагин в плазме крови не обнаруживается. Однако, значения L-аспарагиназы, доступные для определения, сохраняются в плазме в течение как минимум 15 дней после первого введения вещества (в течение 15 дней после первого введения Онкоспара измеряли уровень L-аспарагиназы в плазме)
Путь выведения препарата не установлен. Фермент не определяется в моче.

Фармацевтические характеристики

Раствор для в/в и в/м введения прозрачный, бесцветный или слегка опалесцирующий.

Упаковка, срок годности,
условия хранения

5 мл — флаконы (1) — пачки картонные.
Хранить в недоступном для детей месте, в холодильнике (2–8 °С). Не замораживать. НЕ ВСТРЯХИВАТЬ! Неиспользованные остатки необходимо уничтожить.

Не использовать: если он хранился более 48 ч при комнатной температуре; если раствор стал непрозрачным; при возникновении осадка.

 

 

 

 

Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.

Заказать и купить  Онкаспар (Пэгаспаргаза) в Алматы

Заказать и купить Онкаспар (Пэгаспаргаза) в Казахстане

Позвоните и узнайте цену Онкаспар (Пэгаспаргаза)

Работаем и отправляем Онкаспар (Пэгаспаргаза 3750Е) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Онкаспар (Пэгаспаргаза 3750Е)  по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.

 

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    Regularly check your targets and modify your cut up to keep enhancing.

    Stability muscle groups, permit sufficient restoration, and mix compound and isolation exercises.
    Novices discover a 3-day cut up great for structured training and
    recovery.
    If you resolve to go for a 5 day split and you are feeling fatigued after a
    couple weeks, place a relaxation day in-between each 2 exercise classes.
    It’s nice if you complete your split routine in 8
    or 9 days rather than 7. Most individuals do completely
    nice with a 5 day exercise as a outcome of the exercises
    are so centered on one space of your physique and there’s
    plenty of restoration, so it’s onerous to overtrain.
    So, you are looking at round minutes per workout, not including heat up and cool down. It’s
    essential to remember; you can have the right programme, but a perfect programme by no means completed
    is rendered ineffective. So, choose a exercise frequency that fit your expertise, preferences
    and time constraints so as to push yourself in your workouts,
    recuperate properly and get results. Training sessions needn’t be hours lengthy both to see benefits.
    Whether you’re utilizing bodyweight workout routines
    or weights, full body workouts are versatile and efficient.
    Squat workout routines just like the back squat and the front squat contain the hip, knee, and ankle joints and recruit a number of
    main muscle teams within the decrease body.
    Muscular Tissues require both exercise and rest to totally function and generate energy.
    Many giant muscle group exercises are thought of compound workouts, named so as a result of they also engage
    the big muscles’ complementary muscle groups together with multiple joints.

    Meaning, all pushing muscular tissues on the same day,
    then all pulling muscle tissue.
    When it involves performing a full-body exercise, are
    we really hitting each necessary moves? There’s a slight chance that in our seek for creating the simplest workout
    in the shortest amount of time, effectiveness at instances gets sacrificed for effectivity.

    The face pull is an incredible exercise to strengthen your posterior deltoids, higher trapezius, and rotator cuff muscle tissue.

    This is called periodization and it’s important to avoiding overtraining, it would not matter what health stage you’re.
    You can even design a strength coaching program, by pairing muscles by opposing pressure.
    Opposing muscle tissue, also known as «antagonists» may be considered anterior and posterior
    of one another based on their anatomical positioning.

    With an additional day of training to play with, you can even get extra artistic with your workouts, including
    in some extra selection, or alternating between heavy weight and high rep days.

    Regardless, due to its nature, a bro break up requires a high training frequency to train every body part weekly.
    The bent-over barbell row works lots of the antagonists of the bench press exercise, and is beneficial
    for evening out the power and muscle stability across your higher
    physique. Now that you know which muscle groups to work
    out collectively, you might want slightly guidance getting began.
    The extra you split up and isolate the muscular tissues
    as the primary focus for every workout, the much less relaxation days you’ll doubtless have to take.
    The more muscle tissue worked in every workout, such as a full physique workout, the extra rest days you’ll likely
    need. If you do not plan accordingly, and select to train your arms and shoulders the next day …
    This can enhance your threat of damage and hinder your restoration. So
    if you’re coaching three days per week, coaching a single muscle group per session makes very little sense.

    And particularly whether or not or not you need to prepare muscle groups as
    soon as a week, or a quantity of occasions in a
    7 day interval. This technique divides workouts into classes that target muscles involved in pushing actions and those concerned in pulling movements.
    One Other boon of the standing cable chest fly is that it’s easy to maintain constant
    tension on the muscular tissues throughout the whole
    vary of movement. Properly, that is a tiny muscle, situated beneath your
    pectoralis main. It originates from your high 2–4 ribs and inserts
    on the coracoid process in your scapula. Its main capabilities are to protract your scapula and rotate your scapula forward.
    In phrases of chest hypertrophy and power training, the pectoralis minor is often negligible,
    and likewise often skilled by comparable workouts as your pectoralis
    main anyway.

    References:

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