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Нексавар — Nexavar (сорафениб) по 200мг

Нексавар ( Nexavar) 200мг сорафениб Байер, Германия

Нексавар — Nexavar (сорафениб) по 200мг

Таблетки Нексавар с веществом сорафениб – это противоопухолевое средство (ингибитор протеинкиназы с кодом АТХ:L01XE05), применяемое при лечении некоторых опухолей. Его применяют для уменьшения опухолевых клеток. Также его часто используют при раке печени и почек.

Категория:

Описание

Таблетки Нексавар с веществом сорафениб – это противоопухолевое средство (ингибитор протеинкиназы с кодом АТХ:L01XE05), применяемое при лечении некоторых злокачественных опухолей. Его применяют для уменьшения опухолевых клеток. Также его часто используют при раке печени и почек.

Купить Нексавар (сорафениб) можно в виде двояковыпуклых круглых таблеток с красной пленочной оболочкой.

В одной таблетке присутствует:

  • активное вещество: сорафениба тозилат 274 мг (равен сорафениба основания 200 мг)
  • дополнительно содержит: натрия кроскармеллоза, целлюлоза микрокристаллическая, магния стеарат, гипромеллоза (5 cP), гипромеллоза (15 cP), натрия лаурилсульфат

Показания к применению Нексавар (сорафениб)

  • Рак местно-распространенный, а также метастатический дифференцированный щитовидной железы, резистентный к радиоактивному йоду.

  • Рак печеночно-клеточный.

  • Рак метастатический почечно-клеточный.

Фармакокинетика препарата Нексавар (сорафениб)

При приеме вещества сорафениб средняя относительная биодоступность его составляет 38-49 процентов. Время полувыведения сорафениба составит от 25 до 48 часов. Последующее применение препарата в течение 7 дней после первого приема приводило к росту накопления по сравнению с приемом однократной дозы в 2,5-7 раз.

Равновесные концентрации препарата в плазме крови достигаются в течение  следующих 7 дней после приема, соотношение максимальной/минимальной концентрации равно не более 2.

Фармакокинетику вещества сорафениб в равновесном состоянии в дозах 400 мг по 2 раза в сутки при приеме внутрь анализировали у пациентов с почечно-клеточным раком , печеночно-клеточным раком и раком щитовидной железы. Самую высокую экспозицию замечали у пациентов с раком щитовидной железы, хотя вариация экспозиции была большой при опухолях всех видов. У больных раком щитовидной железы клиническое значение большей площади под кривой «концентрация — время» (AUC) не установлена.

Фармакодинамика препарата Нексавар (сорафениб)

Уменьшение пролиферации опухолевых клеток in vitro происходит по причине того, что вещество Сорафениб является мультикиназным ингибитором.

Известно, что активное вещество Сорафениб  подавляет многочисленные внутриклеточные киназы: c-CRAF, BRAF и мутантную BRAF, а также киназы, которые расположенные на поверхности клеткок, таких как: KIT, FLT- 3, RET, VEGFR-1, VEGFR-2, VEGFR-3 и PDGFR-β. Предполагают, что часть из этих киназ используются в сигнальных системах опухолей, в процессах апоптоза и ангиогенеза. Вещество подавляет увеличение опухоли при дифференцированном раке щитовидной железы, почечно-клеточном раке и печеночно-клеточном раке организма.

Возможно применение с другими противоопухолевыми препаратами:

  • Паклитаксел / карбоплатин

  • Капецитабин

  • Доксорубицин / иринотекан

  • Доцетаксел

  • Неомицин

  • Омепразол

 

Упаковка, хранение, срок хранения Нексавар (сорафениб)

  • Препарат выпускается в таблетках покрытых пленочной оболочкой по 200 мг (28 таблеток в блистере). В пачку с инструкцией по применению размещают по 1, 2 или 4 блистера.
  • Хранить при температуре не выше 25°С в недоступном для детей месте 3 года.

 

Необходимо помнить, что применение препарат необходимо согласовать с лечащим врачом. 

Заказать и купить Нексавар (сорафениб) в Алматы

Заказать и купить Нексавар (сорафениб) в Казахстане

Позвоните и узнайте цену Нексавар (сорафениб)

Работаем и отправляем Нексавар (сорафениб) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Нексавар (сорафениб) по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.

 

Детали

Производитель

Bayer

Страна производитель

Германия

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    Caffeine can improve focus, performance, and restoration working with
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    Once More, it’s not going to hurt you, and it would assist,
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    Whereas BCAAs have been promoted by sports researchers up to now, new
    research have proven that EAAs are a greater choice between the two.

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    It’s additionally important for customers to maintain a tally of their total ingestion of certain elements such as caffeine and niacin, as too much of each of these dietary
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    However, it’s essential to make use of them as directed and contemplate any private
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    Creatine is a naturally occurring substance that plays a critical position in power
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    Prospects find that the product works well for getting them ready for exercises.

    The power level is good, with no letdown throughout their exercises.

    The saline content provides a fast punch of power without the jitters or tingling effect.

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    In other words, creatine gives you the vitality to put within the
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    You need to get another dose of BCAAs post-workout—but the ratio have to be
    correct. The extra of these receptors you have in your muscle cells, the more of your
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    Research reveals that muscles with higher levels of carnosine can generate
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    Some find it sweeter than bitter, with about as much caffeine as a cup of coffee.

    Clients like the standard elements of the nutritional complement.
    The supplement is evident about its components without any proprietary blends.

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    Consider your particular health targets when deciding whether to combine these supplements.

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    It Is important to know the interactions between totally
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    When creatine monohydrate sits in your intestine and isn’t taken up, water gets drawn into the intestines.
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    If you have accomplished considered one of my exercises, you understand at the end you are fully wasted.
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    More ATP means extra reps, more weight, and extra muscle development over time.
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    Lowered recovery occasions from creatine dietary supplements additionally allow you to to push your self additional and more regularly.
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    Supplementing with creatine will increase the stores of creatine throughout
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    When it comes to train, the muscular tissues have a small amount
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    depth bouts of exercise. Customers report stomach discomfort
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    These findings counsel that the SUP may delay fatigue throughout strenuous exercise.
    Most of the products beneath, whether mass gainers or traditional whey protein powders, require you to take
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    It’s typically used to assist gut well being and integrity, especially
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    or restoration. They say it has real doses of creatine, BCAAs, and the tingly stuff.
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    In the past few years, many various versions of creatine have
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    Most of those are both exaggerated or totally false and
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    Amongst all these combinations, including Tongkat Ali to your creatine complement stands out
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    Regardless Of the drawbacks, combining creatine
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    This abdomen sensitivity concern is why I actually have 3 grams of glutamine in Publish JYM.
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    When we’re speaking bout BCAAs, leucine is really the star of the bunch since it’s the ignitor of muscle protein synthesis.
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