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Алтузан /Авастин/ — Altuzan (Бевацизумаб) 100мг и 400мг

Алтузан (Бевацизумаб)
Алтузан (Бевацизумаб)

Алтузан /Авастин/ — Altuzan (Бевацизумаб) 100мг и 400мг

Препарат Алтузан/Авастин — рекомбинантное гуманизированное моноклональное антитело, селективно связываещийся и нейтрализующий биологически активный фактор роста эндотелия сосудов (ФРЭС/VEGF). Лекарство Алтузан снижает васкуляризацию и угнетение роста опухолии путем ингибирования связывания фактора роста эндотелия сосудов с его рецепторами на поверхности эндотелиальных клеток.

Применение бевацизумаба влечет за собой угнетение метастатического прогрессирования болезни и уменьшению микрососудистой проницаемости при разных опухолях человека, включая рак ободочной кишки, молочной железы, поджелудочной и предстательной железы и некоторыми другими онкозаболеваниями.

Категория:

Описание

Препарат Алтузан/Авастин — рекомбинантное гуманизированное моноклональное антитело, селективно связываещийся и нейтрализующий биологически активный фактор роста эндотелия сосудов (ФРЭС/VEGF). Лекарство Алтузан снижает васкуляризацию и угнетение роста опухолии путем ингибирования связывания фактора роста эндотелия сосудов с его рецепторами на поверхности эндотелиальных клеток.

Мед. препарат выпускают в виде концентрата для разведения с последующим приготовлением жидкости для инфузий, активным веществом которого является Бевацизумаб (Bevacizumab). Бевацизумаб содержит полностью человеческие каркасные участки с определяющими комплементарными участками гиперхимерного антитела мыши, которые связываются с ФРЭС/ VEGF.

Применение бевацизумаба влечет за собой угнетение метастатического прогрессирования болезни и уменьшению микрососудистой проницаемости при разных опухолях человека, включая рак ободочной кишки, молочной железы, поджелудочной и предстательной железы и некоторыми другими онкозаболеваниями.

Показания

Показаниями к применению препарата  являются:
• при колоректальном раке с метастазами в сочетании с терапией на основе фторпиримидина
• при местном или метастатическом РМЖ в сочетании с паклитакселом
• при неплоскоклеточном НКРЛ наряду с химиотерапией на основе платиносодержащих веществ
• при почечно-клеточной опухоли в сочетании с интерфероном альфа-2а
• как монотерапия при глиобластоме, комбинируя с либо в сочетании с радиотерапией, темозоломидом, иринотеканом.
• при терапии эпителиальной онкологии яичника, брюшины и трубы матки. В зависимости от болезни, препарат комбинируют с паклитакселом и карбоплатином, паклитакселом, топотеканом, карбоплатином и гемцитабином или пегилированным липосомальным доксорубицином.

Фармакодинамика

Бевацизумаб получают из клеткок яичников китайского хомячка, по технологии рекомбинантной ДНК в системе для экспрессии. Молекулярная масса Бевацизумаба приблизительно 149 000 Да, он состоит из 214 аминокислот. Бевацизумаб селективно связывается с человеческим фактором роста эндотелия сосудовФРЭС/VEGF и ингибирует его биологическую активность. Бевацизумаб на поверхности эндотелиальных клеток подавляет связывание ФРЭС/VEGF с его рецепторами Flt-1 (рецептор ФРЭС-1) и KDR (рецептор ФРЭС-2). Нейтрализация биологической активности ФРЭС/VEGF уменьшает васкуляризацию новообразования, таким образом, ингибируя рост.

Использование бевацизумаба или его исходного антитела мыши на ксенотрансплантантных опухолевых моделях у «бестимусных мышей» вызвало широкую противоопухолевую активность при различных новообразованиях, включая рак толстой кишки, молочной железы, поджелудочной и предстательной железы. Метастатическое прогрессирование заболевания было ингибировано, а микрососудистая проницаемость снижена.

Фармакокинетика

У лиц с различными сóлидными опухолями изучалась фармакокинетика препарата Алтузан в различных дозах: 0,1–10 мг/кг каждую неделю; 3–20 мг/кг каждые 2 или 3 нед; 5 мг/кг каждые 2 нед или 15 мг/кг каждые 3 недели.

Фармакокинетика бевацизумаба, как и других антител, описывается двухкамерной моделью. Распределение препарата Алтузан характеризуется низким клиренсом, низким объемом распределения (Vс) и длительным периодом полувыведения T1/2. Это позволяет добиться поддержания необходимой стабильной терапевтической концентрации препарата в плазме при введении лекарственного вещества один раз в 2–3 недели. Клиренс бевацизумаба не зависит от возраста пациента.

Высокая опухолевая нагрузка и низкий уровень альбумина, чаще всего указывают на степень тяжести заболевания. По сравнению со среднестатистическими пациентами со средними величинами уровня альбумина и опухолевой нагрузки, клиренс бевацизумаба был приблизительно на 30% выше у пациентов с низкими уровнями сывороточного альбумина и на 7% выше у таковых с более высокой опухолевой нагрузкой.

Фармакокинетический популяционный анализ не обнаружил значимых различий в фармакокинетике бевацизумаба по отношению к возрасту (корреляция между клиренсом бевацизумаба и возрастом пациента отсутствует).

Метаболизм

После однократного внутривенного введения 125I-бевацизумаба оценка метаболизма бевацизумаба у кроликов продемонстрировала, что его метаболический профиль похож с таковым природной молекулы IgG, которая не связывается с ФРЭС. Основываясь на данные, полученных у человека, предполагают, что бевацизумаб подвергается метаболизму и выведению схожими с эндогенным IgG. Распад антител идет главным образом путем протеолиза во всем организме, включая эндотелиальные клетки, и их распад не зависит от выведения печенью или почками. Соединение IgG с неонатальным Fc-рецептором сохраняет его от распада, тем самым обеспечивая длительный период полувыведения.

Выведение

В диапазоне доз от 1.5 до 10 мг/кг/неделю фармакокинетика бевацизумаба является имеет линейный характер. В соответствии с двухкамерной моделью период полувыведения составляет 20 дней для среднестатистического мужчины и 18 дней для среднестатистической женщины.

Фармацевтические характеристики

Прозрачная или опалесцирующая жидкость, бесцветная или светло-коричневого цвета.

Упаковка, срок годности, условия хранения

Концентрат для приготовления раствора по 100 мг/4 мл и 400 мг/16 мл. Препарат разлит в стеклянные флаконы, закупоренные пробкой из бутилкаучука, ламинированного фторполимером, обжатых алюминиевым колпачком и закрытых пластмассовой крышкой. Один флакон вместе с инструкцией по применению помещен в пачку картонную.

Срок годности 2 года. Не использовать по истечении срока годности, указанного на упаковке.
Хранить при температуре 2-8°С в защищенном от света месте. Не замораживать.
Хранить в недоступном для детей месте.

 

 

 

 

Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.

Заказать и купить Алтузан /Авастин/ (Бевацизумаб) в Алматы

Заказать и купить Алтузан /Авастин/ (Бевацизумаб) в Казахстане

Позвоните и узнайте цену Алтузан /Авастин/ (Бевацизумаб)

Работаем и отправляем Алтузан (Бевацизумаб) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
а также можем отправить Алтузан (Бевацизумаб) по регионам Казахстана: Нур-Султан (Астана), Шымкент, Талдыкорган, Актау и другие.

Детали

Производитель

Roche Pharma

Страна производитель

Швейцария

Тип

Флакон

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    or pushup) are nice for strength, when you consider it, the standing
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    I’m Pat Chadwick, a professional Stage 2 and Stage three calisthenics coach and certified private trainer from London, England.
    I actually have over six years of expertise training students specifically in the art of calisthenics.
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    For the tough task of concentrating on your inner chest, go for dumbbell
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    Here, the single-arm fly is paired with a single-arm
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    The muscle’s medial head has a significant position, although all three heads come into play when the burden is heavy and the velocity of movement will increase.

    The two actions are remarkably similar, however
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    The bench press is a great chest exercise, and should you increase the weight
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    In this part, we’ll take a look at 4 of the most effective chest workouts, that complement one
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    To carry out the wide grip bench press with correct type, begin by lying flat on a bench along with your feet flat
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    In the shoulder girdle, the pectoralis minor and serratus anterior are the most important muscle tissue involved.

    The small pectoralis minor is situated in the higher chest and is
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    Not sure which workout routines will work finest on your present fitness level?

    The internal chest is often a stubborn space to build because it has larger and stronger fibers that require far more work
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    Failing to take action can put undue stress on other muscle teams and restrict the effectiveness of the exercise.

    My major focus when doing this train is making
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    This unique feature makes them extremely environment friendly for attaining a variety of health goals, together with muscle gain, fats
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    TUT refers again to the duration your muscle tissue are
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    grow. Push-ups are a classic bodyweight exercise that not only strengthen your
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    In essence, incorporating the correct vary of movement into your chest exercises
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    I was skeptical at first, too, but as quickly as I added these to my routine, I
    noticed a noticeable distinction in my chest definition. To construct the internal chest with push-ups, you need to give attention to
    using a close-grip hand placement. This train targets the inside chest while additionally participating core stability and shoulder power.
    This requires more core activation whereas additionally transferring more of the load to your pecs,
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    We can do that by making sure we choose workouts that comply with the varying orientations of the higher, mid and
    decrease chest fibers. There is a LOT more to chest coaching than you might think, especially if you’ve found
    your pecs are sluggish to develop. There are dozens of workouts you would do on chest day,
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    You just wish to know the best exercises to build a muscular chest, so we have accomplished the work to check them
    for you. It comes into play when lifting heavier weights, for instance,
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    That means your pecs could have less assist from your decrease body, and
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    push-up. Be A Part Of Pat Chadwick as he takes you through his inner chest
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    of the chest muscle. If your chest lacks definition, then this might be the key to
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    That’s as a end result of muscle tissue burns more energy than fat tissue
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    A set of dumbbells is an excellent complement to barbells for a chest
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    The incline cable bench press is similar idea because the flat bench press.
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    Abduction is what aliens do, they take one thing away from Earth, so
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    Barbell flat bench presses are nice for more than just displaying off in the gym by urgent heavy weights.
    The dumbbell flat bench exercise levels issues out in comparison with our earlier alternatives for one of the best chest exercises, requiring using
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    This routine is a good stability problem that forces you to
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    Strength coaching and weightlifting at least twice per week to construct muscle is amongst the best ways to extend your calorie expenditure.

    But, if you can perform this traditional bodyweight exercise, you
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