Описание
Косентикс — новый современный препарат для лечения псориаза. Препарат Косентикс (секукинумаб) эффективно уменьшает симптомы псориаза. Данный лекарственный препарат был одобрен в январе 2015 года, и уже более 80 тысяч пациентов прошли лечение с его применением. Препарат представляет собой ингибитор IL-17A. Действующее вещество препарата – секукинамаб — обладает способностью высокоселективно связываться с рецепторами белка IL-17A, участвующим в воспалительном процессе. Тем самым секукинамаб блокирует связывание IL-17A со своими рецепторами, ингибируя его способность запускать воспалительную реакцию. Таким образом, подавляется его действие, приводящее к развитию воспалительных реакций, которые приводят к развитию бляшечного псориаза.
Безопасность и результативность использования Косентикса были исследованы и установлены в четырех клинических экспериментах, с участием 2 403 пациентов, страдающих бляшечным псориазом и являющихся кандидатами на фототерапию или системную терапию. По данным исследований применение этого препарата в контрольных группах пациентов показало намного более выраженные результаты, чем лечение без его применения. Более чем у 90% больных бляшечным псориазом после терапии Косентиксом наблюдалось практически полное исчезновение кожных проявлений этого заболевания. Участники были случайным образом распределены в две группы: одни получали Косентикс, а другие – плацебо. Согласно полученным результатам, клиническая эффективность Косентикса оказалась высокой: было достигнуто полное или практически полное очищение кожи.
Ввиду того, что Косентикс является препаратом, воздействующим на иммунную систему, его упаковка препарата содержит предупреждение о повышенном риске развития инфекционных заболеваний.
Состав Косентикс
- Действующее вещество: секукинумаб;
- вспомогательные вещества: трегалозы дигидрат, гистидин/гистидина гидрохлорида моногидрат, метионин, полисорбат-80, вода для инъекций.
Показания к применению Косентикс
- При псориазе среднетяжелой и тяжелой степени у взрослых пациентов, которым показана системная терапия или фототерапия.
- При активном псориатическом артрите. Как в монотерапии или в комбинации с метотрексатом у взрослых пациентов.
- При активном анкилозирующем спондилита у взрослых пациентов при недостаточном ответе на стандартное лечение.
Фармакодинамика
Секукинумаб — это полностью человеческое иммуноглобулин G1, IgG1, который избирательно связывается и нейтрализует провоспалительный цитокин — интерлейкин-17A. ИЛ-17A играет ключевую роль в патогенезе бляшечного псориаза, псориатического артрита и анкилозирующего спондилита. Секукинумаб подавляет освобождение провоспалительных цитокинов, хемокинов и медиаторов повреждения тканей, тем самым и снижает аутоиммунные и воспалительные реакции. Прямым результатом лечения секукинумабом является снижение выраженности покраснения, шелушения и уплотнения кожи.
Использование препарата Косентикса у лиц с бляшечным псориазом в дозе 300 мг предоставляет более выраженное очищение кожных покровов по сравнению с использованием в дозе 150 мг, с максимальным результатом на 16 неделе. При использовании препарата Косентикса отмечается улучшение симптомов заболевания, улучшение качества жизни, связанное с функциональными возможностями и состоянием здоровья, а также замедление поражения периферических суставов.
Вследствие замедления клиренса, связанного с секукинумабом ИЛ-17А, концентрация общего ИЛ-17А (свободного и связанного с секукинумабом) в крови увеличивается в пределах 2-7 дней, что свидетельствует о том, что секукинумаб селективно связывается со свободным ИЛ-17А. Согласно исследованиям у лиц с бляшечным псориазом после одной-двух недель лечения секукинумабом значительно снижалась инфильтрация эпидермиса нейтрофилами. На фоне лечения секукинумабом у лиц с псориатическим артритом и анкилозирующим спондилитом в течение 1-2 недель наблюдалось понижение концентрации С-реактивного белка.
Фармакокинетика
Всасывание
При бляшечном псориазе после однократного подкожного введения в дозировке 150 мг или 300 мг максимальная концентрация секукинумаба в сыворотке составляла соответственно 13,7±4,8 мкг/мл или 27,3±9,5 мкг/мл в интервале между 5 и 6 днем после ввeдения. во время первого месяца максимальная концентрация достигалась между 31 и 34 днем при еженедельном введении после первоначального введения. Максимальная концентрация в равновесном состоянии после подкожного введения 150 мг или 300 мг составила 27,6 мкг/мл и 55,2 мкг/мл и достигалась после 20 недель при ежемесячном введении. Пo сравнению с экспозицией после однократной дозировки, отмечено двукратное увеличение площади пoд фармакокинетической кривой «концентрация-время» (AUC) и максимальной концентрации пoсле многократного ежемесячного введения вo время поддерживающего лечения. Секукинумаб всасывается со средним показателем абсолютной биодоступности 73%.
Распределение
После однократного внутривенного введения средний объем распределения в терминальной фазе (Vz) варьировал между 7,10 и 8,60 л у лиц с бляшечным псориазом, возможно потому что секукинумаб ограниченно распределяется на периферии. У пациентов с бляшечным псориазом концентрации секукинумаба в межклеточной жидкости кожи варьировали от 28% до 39% от таковой в сыворотке на 1-2 неделе после однократного подкожного введения в дозировке 300 мг.
Выведение
Средний системный клиренс (CL) у лиц с бляшечным псориазом составил 0,19 л/сутки. Средний период полувыведения у лиц с бляшечным псориазом составлял 27 дней. У отдельных пациентов с псориазом расчетный период полувыведения варьировал от 17 до 41 дня.
Линейность / нелинейность
У лиц с бляшечным псориазом фармакокинетические параметры при однократном и многократном введении секукинумаба определялись в нескольких исследованиях с внутривенным введением в дозировках от 1×0,3 мг/кг до 3×10 мг/кг и с подкожным введением в дозировках, от 1×25 мг до многократной дозы 300 мг. При всех режимах дозирования экспозиция была пропорциональна дозе. У лиц с псориатическим артритом, анкилозирующим спондилитом и бляшечным псориазом фармакокинетические параметры секукинумаба одинаковы.
Фармакокинетика в особых клинических случаях
Пациенты старше 65 лет
По результатам популяционного фармакокинетического анализа клиренс у пациентов старше 65 лет и пациентов моложе данной возрастной группы был одинаков.
Пациенты с нарушениями функции печени или почек
Данных по фармакокинетике секукинумаба у пациентов с нарушениями функции печени или почек нет.
Пациенты моложе 18 лет
Не установлена безопасность и эффективность лекарства у детей до 18 лет.
Фармацевтические характеристики
Раствор для подкожного введения. Раствор прозрачный или опалесцирующий, от бесцветного до светло-желтогo цвета.
Упаковка, срок годности, условия хранения
Препарат упакован в предварительно заполненный шприц с устройством для пaссивной защиты иглы. После введения препарата, автоматическое защитное устройство шприца активируется и скрывает иглу.
Хранить в закрытой оригинальной упаковке для защиты от света. Храните упаковку в холодильнике при температуре от 2°C до 8°C, в местах, не доступных для детей. Не замораживать. Не встряхивать. Не используйте препарат если автоинжектор упал без колпачка. Во избежание дискомфорта при введении, можно предварительно достать препарат из холодильника и оставьте при комнатной температуре в тeчение 15–30 минут. Не снимайте колпачок до тех пор, пока не будете готовы ввести лекарство. Препарат может храниться до 4 дней вне холодильника, при комнатной температуре до 30°С.
Не используйте с препарат после истечения срока годности.
Хранить и перевозить Косентикс следует при температуре 2-8 0С. Препарат нельзя подвергать вибрации, воздействию прямого солнечного света и замораживать.
Важная информация по безопасности
Внимание: храните препарат в недоступном для детей месте. Колпачок иглы шприца может содержать сухой каучук (латекс). Не открывайте запечатанную пачку, пока Вы не будете готовы использовать препарат. Не используйте препарат при нарушении целостности, это небезопасно. Не оставляйте препарат в местах доступных для других. Не встряхивайте предварительно заполненный шприц. Не прикасайтесь к защитным лапкам шприца до использования. Не снимайте колпачок с иглы до момента использования. Недопустимо повторное использование предварительно заполненного шприца.
Наша компания работает как на территории Казахстана, так и осуществляет доставку в страны ближнего зарубежья. Обращайтесь к нам за консультациями по контактным телефонам.
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Позвоните и узнайте цену Косентикс (Секукинумаб)
Работаем и отправляем Косентикс (Секукинумаб) по странам СНГ: Россия, Украина, Кыргызстан (Бишкек), Белоруссия, Узбекистан (Ташкент),
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